Researchers in the University of Pennsylvania's's Department of Computer & Information Science focus on a broad array of research areas in theoretical computer science. The CS Theory Research Group has active projects spanning the domains of algorithms, combinatorial optimization, complexity theory, machine learning, algorithmic game theory, communication complexity, cryptography, and coding theory.

Many of the group's members are also affiliated with Penn's Warren Center for Network and Data Sciences, the Networked and Social Systems Engineering program, Penn Research in Machine Learning, the Logic and Computation Group at Penn, and the Security Laboratory.